Tissue Doppler Imaging Predicts the Development of Hypertrophic Cardiomyopathy in Subjects With Subclinical Disease
- 29 July 2003
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Circulation
- Vol. 108 (4) , 395-398
- https://doi.org/10.1161/01.cir.0000084500.72232.8d
Abstract
Background— Systolic (Sa) and diastolic (Ea) myocardial velocities measured by tissue Doppler (TD) imaging (TDI) recently were shown to be decreased in subjects who have mutations causing hypertrophic cardiomyopathy (HCM) but who do not have left ventricular (LV) hypertrophy. By studying these subjects at a later date, we sought to determine whether TDI predicts the subsequent evolution of the HCM phenotype. Methods and Results— Serial 2D and Doppler echocardiography were performed in 12 subjects (age range, 17 to 51 years) with HCM-causing mutations on 2 occasions: before development of hypertrophy and 2 years later. Twelve age- and gender-matched family members without mutations were included as control subjects. In those with mutations, mean septal thickness and LV mass were 1.07±0.14 cm and 103.0±11 g at baseline, respectively, and increased to 1.30±0.36 cm and 193.0±78 g at follow-up (P<0.01), with 6 subjects satisfying HCM diagnostic criteria. Sa and Ea velocities in those with mutations were lower ...Keywords
This publication has 12 references indexed in Scilit:
- Usefulness of Doppler myocardial imaging for identification of mutation carriers of familial hypertrophic cardiomyopathyThe American Journal of Cardiology, 2002
- Assessment of Diastolic Function With Doppler Tissue Imaging to Predict Genotype in Preclinical Hypertrophic CardiomyopathyCirculation, 2002
- The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse modelJournal of Clinical Investigation, 2002
- The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse modelJournal of Clinical Investigation, 2002
- Tissue Doppler Imaging Consistently Detects Myocardial Abnormalities in Patients With Hypertrophic Cardiomyopathy and Provides a Novel Means for an Early Diagnosis Before and Independently of HypertrophyCirculation, 2001
- Simvastatin Induces Regression of Cardiac Hypertrophy and Fibrosis and Improves Cardiac Function in a Transgenic Rabbit Model of Human Hypertrophic CardiomyopathyCirculation, 2001
- The Molecular Genetic Basis for Hypertrophic CardiomyopathyJournal of Molecular and Cellular Cardiology, 2001
- A transgenic rabbit model for human hypertrophic cardiomyopathyJournal of Clinical Investigation, 1999
- Doppler Estimation of Left Ventricular Filling Pressures in Patients With Hypertrophic CardiomyopathyCirculation, 1999
- Recommendations for Quantitation of the Left Ventricle by Two-Dimensional EchocardiographyJournal of the American Society of Echocardiography, 1989