An Analysis of the Interaction between Two Nitrosourea Compounds and X-radiation in Rat Brain Tumour Cells

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Abstract
BCNU [1,3-bis(2-chloroethyl)-1-nitrosourea] and CCNU [1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea] are toxic in rat 9L brain tumor cells and sensitize these cells to the action of ionizing radiation. The interaction of BCNU and CCNU with radiation was interpreted using a recently developed extension of the molecular theory of cell survival. The experimental results are compatible with the mathematical equations predicted by the model; the analysis indicates that the sensitizing effect is caused by a synergistic interaction between sublethal damage caused by the nitrosourea compound and the radiation at the molecular level. The analysis of the dependence of the interaction on the time between nitrosourea treatment and radiation indicates that the optimal interaction occurs with a 5 h interval.

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