AUTOANTIBODIES TO LIVER-SPECIFIC LIPOPROTEIN FOLLOWING HEPATITIS INDUCED BY MOUSE CYTOMEGALOVIRUS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 52  (1) , 89-97
Abstract
Autoantibodies to liver specific lipoprotein (LSP) are produced following acute non-fatal hepatitis in murine cytomegalovirus (MCMV) infected mice. Both C57Bl and BALB/c mice produced a transient LSP autoantibody response demonstrated by passive hemagglutination and enzyme linked immunosorbent assay. C57Bl mice produced both IgM and IgG LSP autoantibody and BALB/c mice produced only IgM autoantibody. The autoantibody was species non-specific, reacting with both mouse and rabbit LSP. Plasma containing LSP autoantibody reacted with the surface of normal mouse hepatocytes by immunofluoresence. This model provides an opportunity for study of LSP autoantibody production during viral hepatitis.