Phase Variation of Hyaluronidase-producing Peptostreptococci Associated with Periodontal Disease

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Abstract
Peptostreptococci isolated from diseased periodontal pockets produced large amounts of extracellular hyaluronidase throughout their growth cycle. Phase variants, obtained by re-streaking aged colonies of the wild types, had different colonial morphology and shorter generation times. These variants produced less hyaluronidase, and enzyme production occurred only during the early stationary phase.