Evolution to predominance of swine influenza virus hemagglutinin mutants of predictable phenotype during single infections of the natural host.
- 1 November 1988
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 85 (21) , 8098-8101
- https://doi.org/10.1073/pnas.85.21.8098
Abstract
L and H2 mutants of the A/NJ/11/76 H1N1 strain of swine influenza virus differ by having either a lysine or a glutamic acid at position 153 of the hemagglutinin glycoprotein of the virus. In two separate experiments, experimental infection of swine with various doses of the H2 mutant resulted in the emergence in 11 of 20 animals of virus with the L phenotype. All evidence indicates that the H2 .fwdarw. L mutation, selection, and evolution to predominance occurred within the 7-day span of individual infections. L and H2 mutations appear to act as alleles in the adaptation of virus, respectively, to natural and laboratory hosts. Although the gradual evolution of mutants during sequential infections is commonplace, the present recognition of rapid and predictable evolution of mutants of increased replication efficiency and specific phenotype in the natural host, to our knowledge, is unprecedented.Keywords
This publication has 16 references indexed in Scilit:
- Hemagglutinin polymorphism as the basis for low- and high-yield phenotypes of swine influenza virus.Proceedings of the National Academy of Sciences, 1988
- Structural changes in the haemagglutinin which accompany egg adaptation of an influenza A(H1N1) virusVirology, 1987
- Host cell-mediated selection of a mutant influenza A virus that has lost a complex oligosaccharide from the tip of the hemagglutinin.Proceedings of the National Academy of Sciences, 1986
- The antigenicity and evolution of influenza H1 haemagglutinin, from 1950–1957 and 1977–1983: Two pathways from one geneVirology, 1986
- Hemagglutinin of swine influenza virus: a single amino acid change pleiotropically affects viral antigenicity and replication.Proceedings of the National Academy of Sciences, 1983
- Single amino acid substitutions in influenza haemagglutinin change receptor binding specificityNature, 1983
- Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variationNature, 1981
- Recent contributions of molecular biology to the clinical virology of myxoviruses.1980
- Genetic dimorphism in influenza viruses: Characterization of stably associated hemagglutinin mutants differing in antigenicity and biological propertiesProceedings of the National Academy of Sciences, 1978
- Swine influenza viruses isolated in 1976 from man and pig contain two coexisting subpopulations with antigenically distinguishable hemagglutininsVirology, 1977