Colony-Stimulating Factor 1-Dependent Cells Protect against Systemic Infection with Listeria monocytogenes but Facilitate Neuroinvasion

1 August 2002

journal article
research article
Published by American Society for Microbiology in Infection and Immunity

Vol. 70 (8) , 4682-4686
https://doi.org/10.1128/iai.70.8.4682-4686.2002

Abstract

By using mice genomically lacking the mononuclear phagocytic growth factor colony-stimulating factor 1 and thereby deficient in macrophage and dendritic cell populations, we show that these cells play a dual role: they constitute a major defense against systemic infection but also facilitate cerebral bacterial invasion by Listeria monocytogenes .

Keywords

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