Anomalous patterns of mammalian oocyte maturation and fertilization

Abstract
This report illustrates some of the errors that may occur during in vivo and in vitro maturation and fertilization of mammalian ova, considers the possible mechanisms accounting for their occurrence, and discusses their functional consequences. Included in the description are anomalies of oocyte and follicular development, i.e., multinucleated oocytes, polyovular follicles, and aberrations of zona pellucida formation. Also considered are deviations from the normal process of oocyte maturation such as chromosomal anomalies, development of abnormal nuclear structures (subnuclei), inhibition of polar body formation and aberrations of polar body structure. Anomalies of the process of fertilization such as polyspermia, sperm penetration into polar bodies, and development of multinucleated blastomeres in two‐cell embryos are also described.

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