Omeprazole Inhibits the Formation of Acid in the Parietal Cell by a Direct Inhibition of the H+K+ATPase, the Acid Pump of the Stomach
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 21 (sup118) , 49-51
- https://doi.org/10.3109/00365528609090888
Abstract
H2-receptor antagonists and antimuscarinic agents are well known antisecretory drugs, exerting their action by blocking cell surface receptors. Recently, substituted benzimidazoles (timoprazole, picoprazole and omeprazole) have been shown to inhibit acid production in vitro in gastric glands from rabbit (1), and acid secretion in vivo in various species including human (2). In the present report of studies on cells isolated from the pig gastric mucosa (3), and on purified membranes containing the H+K+ATPase, it is shown that the substituted benzimidazole, omeprazole, inhibits the production of gastric acid, probably by direct interaction with the H+K+ ATPase, the acid pump.Keywords
This publication has 3 references indexed in Scilit:
- Preparation of cells from pig gastric mucosaActa Physiologica Scandinavica, 1984
- Inhibition of gastric (H+ + K+)-ATPase by the substituted benzimidazole, picoprazoleBiochimica et Biophysica Acta (BBA) - Biomembranes, 1983
- Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man.Gut, 1983