Preclinical warning of recrudescent mammary cancers by pregnancy-associated alpha-macroglobulin
- 1 October 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 63 (10) , 819-822
- https://doi.org/10.1002/bjs.1800631022
Abstract
Nine of 30 mammary cancer patients developed metastases during 13–94 months after mastectomy. All 9 patients had elevated blood levels of pregnancy-associated α-macroglobulin (PAM) 1–21 months before conventional detection of metastases. Seven of the clinically well patients had PAM rises exceeding 90 per cent above the baseline and in 4 of these the PAM later fell to lower levels. PAM appears to have potential as an indicator of the growth of micrometastases.Keywords
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