Constitutive and Interleukin-1-inducible Phosphorylation of p65 NF-κB at Serine 536 Is Mediated by Multiple Protein Kinases Including IκB Kinase (IKK)-α, IKKβ, IKKϵ, TRAF Family Member-associated (TANK)-binding Kinase 1 (TBK1), and an Unknown Kinase and Couples p65 to TATA-binding Protein-associated Factor II31-mediated Interleukin-8 Transcription
Open Access
- 1 December 2004
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 279 (53) , 55633-55643
- https://doi.org/10.1074/jbc.m409825200
Abstract
No abstract availableKeywords
This publication has 56 references indexed in Scilit:
- Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF- B activation and transformation in resistant JB6 cellsCarcinogenesis: Integrative Cancer Research, 2004
- Human T-cell Lymphotropic Virus Type 1 Tax Induction of Biologically Active NF-κB Requires IκB Kinase-1-mediated Phosphorylation of RelA/p65Journal of Biological Chemistry, 2004
- IκB Kinase-Independent IκBα Degradation Pathway: Functional NF-κB Activity and Implications for Cancer TherapyMolecular and Cellular Biology, 2003
- Phosphorylation of serine 276 is essential for p65 NF- B subunit-dependent cellular responsesBiochemical and Biophysical Research Communications, 2003
- Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38Journal of Biological Chemistry, 2001
- Regulation of NF-κB RelA Phosphorylation and Transcriptional Activity by p21 and Protein Kinase Cζ in Primary Endothelial CellsJournal of Biological Chemistry, 1999
- Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300Molecular Cell, 1998
- p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis FactorJournal of Biological Chemistry, 1998
- The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent MechanismCell, 1997
- SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modelingElectrophoresis, 1997