The effect of oxprenolol and indomethacin on renin and aldosterone of normal subjects during low sodium diet

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Abstract
To study the mechanisms underlying renin and aldosterone increase during low Na diet, 8 normal subjects were studied during normal Na diet (5 g NaCl/day) for 5 days, after 4 days of low Na diet, and, on continuing low Na diet, after randomized treatment with oxprenolol (100 mg), indomethacin (200 mg) and oxprenolol + indomethacin (100 + 200 mg) each given for 24 h with a 48-h interval between each treatment. Renin (PRA) increased significantly after low Na diet and the increase was inversely related to urinary Na excretion. Both oxprenolol and indomethacin significantly reduced PRA to values similar to those during normal Na intake, while the combination of the 2 drugs showed a net additive effect on PRA. PRA decrements after either oxprenolol or indomethacin were significantly related to PRA values after low Na diet while no correlation was present between PRA values after oxprenolol and indomethacin. Aldosterone excretion showed a trend similar to that of PRA, being related to PRA on normal and low Na diet, and to a lesser extent after drug treatment. Both the sympathetic nervous system and prostaglandins may play a permissive role in the regulation of renin and aldosterone of normal subjects on low Na diet.