Antimalarial Activities of Triazine Metabolites of Chlorguanide and Dichlorguanide.
- 1 June 1952
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 80 (2) , 367-370
- https://doi.org/10.3181/00379727-80-19625
Abstract
The activities of the triazine metabolites of chlorguanide and dichlorguanide were studied in Plasmodium cynomolgi infections in the rhesus monkey. The chlorguanide metabolite, CPT, has only 1/2 to 1/4 the activity of the parent drug, whereas the dichlorguanide metabolite, DCPT, has activity equal to that of chlorguanide. These findings are in marked contrast to reported results on P. gallinaceum infections in the chick, against which CPT and DCPT are, respectively 10 and 100 times as effective as chlorguanide.Keywords
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