Activity of gamma interferon in combination with pyrimethamine or clindamycin in treatment of murine toxoplasmosis
- 1 May 1990
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 9 (5) , 358-360
- https://doi.org/10.1007/bf01973746
Abstract
The activity of recombinant gamma interferon (rIFN-γ) in combination with either pyrimethamine or clindamycin was examined in a murine model of acute toxoplasmosis. Mice received either pyrimethamine or clindamycin alone or in combination with rIFN-γ. Significantly increased survival and/or time to death was observed in animals treated with pyrimethamine or clindamycin in combination with rIFN-γ compared to those that received treatment with any of the agents alone.Keywords
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