Studies on Xanthine Oxidase. IX

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Abstract
The action of the xanthine oxidase was tested on a series of substituted purines. There was exhibited a marked specificity, only 2 (6, 8-dihydroxypurine and 2-thio-xanthine) being activated, both of these taking up 1 atom of O for each molecule during their oxidation by this system. Introduction of a CH3 group into the pyrimidine or iminazole ring was sufficient to prevent activation. A study of the adsorption of the purines by the oxidase showed that the complete skeleton[long dash]the 2 ring structure[long dash]is necessary for adsorption. The introduction of an amino group strongly favors adsorption, and the introduction of methyl groups, particularly in the iminazole ring, tends to prevent adsorption.

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