Study of the coinduction by fatty acids of catalase A and acyl‐CoA oxidase in standard and mutant Saccharomyces cerevisiae strains

Publisher Website
Google Scholar
Abstract
Evidence is presented that Saccharomyces cerevisiae can metabolize fatty acids via the inducible peroxisomal .beta.-oxidation pathway even when these acids are not the sole carbon source. The fatty acids of chain length of C10-C18 induce acyl-CoA oxidase simultaneously with catalase A but have no effect on catalase T and acyl-CoA dehydrogenase. The coinduction of both acyl-CoA oxidase and catalase A is recorded in strains with both active catalase A and T or displaying only catalase A activity. In mutants lacking catalase A, the induction of acyl-CoA oxidase is observed without a concomitant increase in catalase activity. After centrifugation in a linear Ficoll gradient of the particulate fraction from the cells grown on ethanol and oleate the activity of acyl-CoA oxidase cosediments with catalase A. The relationship of catalase A to acyl-CoA oxidase is discussed.

This publication has 31 references indexed in Scilit: