Transendothelial transport of 131I-albumin1

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Abstract
One factor of interest relating to arterial disease is the effect of wall shear stress on the transport of large molecules from blood into the arterial wall. If such a shear dependence of wall uptake is operable, this may be related to the fact that certain vascular sites show a greater predilection for the development of atherosclerosis than others. The uptake of 131I-albumin by the arterial wall was measured both in vitro in serum perfused dog common carotid artery and in vivo in the canine aorta. In the former, the emphasis was on determining the shear dependence of albumin uptake by the arterial wall under controlled fluid mechanical conditions. In the latter, on the other hand, it was of interest to demonstrate consistency of the in vitro results with in vivo findings and the magnitude of any whole body vibration effect on blood-arterial wall transport.

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