Changes in the livers of mice after administration of 3:4:5:6-dibenzcarbazole

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Abstract
A single intraperitoneal inj. of 0.25 mgm. 3:4:5:6-dibenzcarbazole per 20 gm. mouse caused an increase in the glutathione content of the liver which was maximal during the first 20 days. This preceded a considerable proliferation of bile ducts which occurred in 40% of the mice examined between the 35th and 200th days. When 0.5 mg. was given there was a similar increase in glutathione content in the majority of the mice but in a few there was a decrease which in most cases was accompanied by a partial necrosis of the liver lobules. This increase in glutathione was not observed in mice injected with 1:2:5:6-dibenzanthracene or with methylcholanthrene. No change in the ascorbic acid or cholesterol of the liver occurred with any of these carcinogenic compounds.

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