The fate of the rodenticide flocoumafen in the rat: Retention and elimination of a single oral dose

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Abstract
A single oral dose of 0.14 mg kg−1 of [14C] flocoumafen to rat, which gave a transient, non‐lethal, effect, was rapidly absorbed, radioactivity appearing in the blood maximally at 4 h and falling to half maximum value by 8 h. The maximum effect on prothrombin time was at 24 h and the value returned to normal by 48 h. Elimination of radioactivity was very slow, with less than 0.5% of the dose in the urine up to 7 days after dosing, and 23‐26% in the faeces (more than half of which appeared in the first 24 h). Most of the administered radioactivity (74‐76%) was retained 7 days after dosing. Approximately half of the dose was in the liver; it was eliminated with a halflife of 220 days. At 48 h after dosing, most of the hepatic radioactivity comprised unchanged flocoumafen. Treatments of flocoumafen‐dosed rats with warfarin or with cytochrome P450‐inducing doses of phenobarbitone were without effect on the hepatic residue of flocoumafen.