Primary Hyperparathyroidism
- 1 June 1972
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 286 (22) , 1169-1175
- https://doi.org/10.1056/nejm197206012862201
Abstract
To achieve preoperative localization of abnormal parathyroid tissue in 33 patients suspected of having primary hyperparathyroidism, blood samples were obtained before operation by catheter from the small veins of the thyroid venous plexus. Parathyroid hormone concentrations in the samples were determined by radioimmunoassay. The correctness of the predicted lateralization was confirmed in all 21 patients who were operated on. A unilateral hormone gradient was seen in patients who had a single adenoma; bilateral gradients were seen in those who had multiple abnormal glands. The technic seems useful for localizing the site of abnormal parathyroid tissue, for preoperative differentiation of a single abnormal gland (adenoma) from multiple abnormal glands (hyperplasia), and it also may be helpful in establishing the existence of hyperparathyroidism in certain patients who pose special diagnostic problems.Keywords
This publication has 13 references indexed in Scilit:
- Parathyroid Hormone: Secretion and Metabolism In VivoProceedings of the National Academy of Sciences, 1971
- PREOPERATIVE LOCALISATION OF PARATHYROID TUMOURSThe Lancet, 1971
- Parathyroid hormone: Sequence, synthesis, immunoassay studiesThe American Journal of Medicine, 1971
- Clinical applications of radioimmunoassay of plasma parathyroid hormoneThe American Journal of Medicine, 1971
- Primary hyperparathyroidism: A prospective clinical studyThe American Journal of Medicine, 1971
- The Anatomic Basis of Parathyroid Venous SamplingRadiology, 1970
- Localization of Parathyroid Adenomas by Selective Venous Catheterization and RadioimmunoassayNew England Journal of Medicine, 1969
- IMMUNOLOGICAL REACTIVITY OF PURIFIED HUMAN PARATHYROID HORMONEProceedings of the National Academy of Sciences, 1969
- Primary HyperparathyroidismNew England Journal of Medicine, 1969
- Selective Superior and Inferior Thyroid Vein CatheterizationInvestigative Radiology, 1969