Plasma cortisol levels in pregnant ewes

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Abstract
Pregnancy toxaemia in ewes is a metabolic disorder which may occur during the last month of pregnancy. Typical symptoms are anorexia, hypoglycaemia, hyperketonaemia, blindness, ataxia and recumbency. The condition usually proves fatal. Reid & Hogan (1959) have put forward the suggestion that pregnancy toxaemia is an adrenal steroid diabetes. However, pregnancy toxaemia in ewes is generally associated with starvation or severe undernutrition, and McClymont & Setchell (1955) have suggested that under these conditions the symptoms of pregnancy toxaemia are due to cerebral depression caused by hypoglycaemia. As part of investigations on pregnancy toxaemia, adrenal steroid metabolism in ewes was studied. This paper presents data on plasma cortisol levels during the last month of pregnancy in ewes, and the possible effects of undernutrition and cold on these levels.