Preparative surgery enhances the direct spinal actions of three injectable anaesthetics in the anaesthetized rat
- 1 July 1991
- journal article
- Published by Wolters Kluwer Health in Pain
- Vol. 46 (1) , 75-80
- https://doi.org/10.1016/0304-3959(91)90036-w
Abstract
In this study we have investigated the influence of preparative surgery on the potency with which a range of injectable anaesthetics depressed nociceptive withdrawal reflexes in anaesthetized, spinalized rats. Drug effects were compared on 2 different preparations, each requiring differing degrees of preparatory surgery. Recordings were made in each case of unitary motoneurone responses to controlled noxious stimuli. The dose-dependent effects of the general anaesthetics alpha-chloralose (20-80 mg/kg i.v.) and alphaxalone/alphadolone (0.5-2 mg/kg) and of the dissociative anaesthetic ketamine (0.5-16 mg/kg) were studied. When the degree of surgical intervention was increased, the reflex response to a uniform mechanical pinch stimulus was facilitated. This enhanced response was more susceptible to the reflex depressant actions of all the compounds studied.Keywords
This publication has 27 references indexed in Scilit:
- The thresholds of the jaw-opening reflex and trigeminal brainstem neurons to tooth-pulp stimulation in acutely and chronically prepared catsNeuroscience, 1990
- Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the ratBrain Research, 1990
- Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the ratBrain Research, 1987
- Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.Neuropharmacology, 1987
- Lack of spontaneous activity of cutaneous spinal dorsal horn neurons in awake, drug-free, spinally transected catsExperimental Neurology, 1987
- WDR response profiles of spinal dorsal horn neurons may be unmasked by barbiturate anesthesiaPain, 1987
- Prolonged C-fibre mediated facilitation of the flexion reflex in the rat is not due to changes in afferent terminal or motoneurone excitabilityNeuroscience Letters, 1986
- The effects of decerebration and destruction of nucleus raphe magnus, periaqueductal grey matter and brainstem lateral reticular formation on the depression due to surgical trauma of the jaw-opening reflex evoked by tooth-pulp stimulation in the catBrain Research, 1985
- The effects of anaesthetics and remote noxious stimuli on the jaw-opening reflex evoked by tooth-pulp stimulation in the catBrain Research, 1985
- The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartateBritish Journal of Pharmacology, 1983