ELEVATED SERUM THYROGLOBULIN AS A MANIFESTATION OF ACUTE HAEMORRHAGE INTO THE THYROID GLAND

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Abstract
Clinical observations and serial determinations of serum thyroglobulin (Tg) were made in 5 patients with acute hemorrhage into the thyroid gland. Fever, local pain and acceleration of erythrocyte sedimentation rate were minimal or were not observed, and serum T4 [thyroxine] and T3 [triiodothyronine] were normal. Although all patients showed an increase in serum Tg, this was most obvious in 3 subjects and it gradually decreased as the nodule became smaller. There was no correlation between the serum Tg concentration and the nodular size. Acute hemorrhage into the thyroid gland should be added as one of the causes to increase serum Tg concentrations.