Sclerosing peritonitis and propranolol

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Abstract
Sclerosing peritonitis developed in a 43 yr old man with angina pectoris who was receiving the .beta.-adrenergic receptor antagonist, propranolol. The patient had abdominal and back pain, weight loss, a midabdominal fullness, ascites and evidence of partial small bowel obstruction. At surgery, the small bowel was distended and encased by dense fibrous tissue. Infectious and neoplastic causes of fibrosing peritoneal inflammation were exluded. The patient described in this report illustrates several features commonly experienced by individuals who developed sclerosing peritonitis associated with .beta.-adrenergic receptor blockade therapy. Development of ascites and considerable ascitic fluid leukocytosis was not described previously with this disorder.