Effect of Glycemic Exposure on the Risk of Microvascular Complications in the Diabetes Control and Complications Trial—Revisited
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Open Access
- 1 April 2008
- journal article
- research article
- Published by American Diabetes Association in Diabetes
- Vol. 57 (4) , 995-1001
- https://doi.org/10.2337/db07-1618
Abstract
OBJECTIVE— The Diabetes Control and Complications Trial (Diabetes 44:968–983, 1995) presented statistical models suggesting that subjects with similar A1C levels had a higher risk of retinopathy progression in the conventional treatment group than in the intensive treatment group. That analysis has been cited to support the hypothesis that specific patterns of glucose variation, in particular postprandial hyperglycemia, contribute uniquely to an increased risk of microvascular complications above and beyond that explained by the A1C level.This publication has 12 references indexed in Scilit:
- Variability in the Relationship between Mean Plasma Glucose and HbA1c: Implications for the Assessment of Glycemic ControlClinical Chemistry, 2007
- The Effect of Glucose Variability on the Risk of Microvascular Complications in Type 1 DiabetesDiabetes Care, 2006
- Glycemic Variability: A Hemoglobin A1c–Independent Risk Factor for Diabetic ComplicationsJAMA, 2006
- Activation of Oxidative Stress by Acute Glucose Fluctuations Compared With Sustained Chronic Hyperglycemia in Patients With Type 2 DiabetesJAMA, 2006
- The relation of glycaemia to the risk of development and progression of retinopathy in the Diabetic Control and Complications TrialDiabetologia, 2001
- Biostatistical MethodsWiley Series in Probability and Statistics, 2000
- The Absence of a Glycemic Threshold for the Development of Long-Term Complications: The Perspective of the Diabetes Control and Complications TrialDiabetes, 1996
- The Relationship of Glycemic Exposure (HbA1c) to the Risk of Development and Progression of Retinopathy in the Diabetes Control and Complications TrialDiabetes, 1995
- The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1993
- Fundus Photographic Risk Factors for Progression of Diabetic RetinopathyOphthalmology, 1991