Association between Hypermutator Phenotype, Clinical Variables, Mucoid Phenotype, and Antimicrobial Resistance in Pseudomonas aeruginosa
- 1 October 2008
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 46 (10) , 3491-3493
- https://doi.org/10.1128/jcm.00357-08
Abstract
The presence of hypermutator Pseudomonas aeruginosa was associated with poorer lung function in patients at the Adult West Midlands CF Unit. Mucoid isolates were more likely to be hypermutators. The presence of resistant mutant subpopulations was associated with hypermutator phenotype but was not good enough to be used as a test for this phenotype.Keywords
This publication has 15 references indexed in Scilit:
- BSAC standardized disc susceptibility testing method (version 5)Journal of Antimicrobial Chemotherapy, 2006
- Efficacy and Potential for Resistance Selection of Antipseudomonal Treatments in a Mouse Model of Lung Infection by HypermutablePseudomonas aeruginosaAntimicrobial Agents and Chemotherapy, 2006
- Alginate lyase enhances antibiotic killing of mucoid Pseudomonas aeruginosa in biofilmsAPMIS, 2006
- Hypermutation Is a Key Factor in Development of Multiple-Antimicrobial Resistance inPseudomonas aeruginosaStrains Causing Chronic Lung InfectionsAntimicrobial Agents and Chemotherapy, 2005
- Occurrence of HypermutablePseudomonas aeruginosain Cystic Fibrosis Patients Is Associated with the Oxidative Stress Caused by Chronic Lung InflammationAntimicrobial Agents and Chemotherapy, 2005
- Phenotypic variability of Pseudomonas aeruginosa in sputa from patients with acute infective exacerbation of cystic fibrosis and its impact on the validity of antimicrobial susceptibility testingJournal of Antimicrobial Chemotherapy, 2005
- Detection and Susceptibility Testing of Hypermutable Pseudomonas aeruginosa Strains with the Etest and Disk DiffusionAntimicrobial Agents and Chemotherapy, 2004
- Alginate Overproduction AffectsPseudomonas aeruginosaBiofilm Structure and FunctionJournal of Bacteriology, 2001
- High Frequency of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Lung InfectionScience, 2000
- The estimation of the bactericidal power of the bloodEpidemiology and Infection, 1938