Genetic background alters the spectrum of tumors that develop in p53‐deficient mice
- 1 July 1993
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 7 (10) , 938-943
- https://doi.org/10.1096/fasebj.7.10.8344491
Abstract
Using gene targeting in embryonic stem cells, we have generated mice with one or two null p53 germ line alleles. Mice with both p53 alleles inactivated are developmentally normal but highly susceptib...Keywords
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