Dietary Treatment of Adult Patients with Phenylketonuria

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Abstract
A pilot study and a subsequent double-blind study have been performed on 7 previously untreated elderly phenylketonuria patients in order to evaluate the effect of phenylalanine-poor diet. The effect of the treatment was evaluated by the observation of 6 psychiatric symptoms according to a 5-grade scale. Good and/or rather good effect of the treatment was noticed in 3 of the patients, while 2 showed only a slight effect during the pilot study. In the subsequent double-blind study on 5 patients, no effect was seen of the treatment with phenylalanine-poor diet. The necessity of double-blind studies in investigations of this kind is discussed.

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