G Protein control of inositol lipids in intact vascular smooth muscle
- 29 October 2001
- journal article
- Published by Wiley
- Vol. 268 (1) , 91-94
- https://doi.org/10.1016/0014-5793(90)80980-w
Abstract
Agonist-induced PIP2, breakdown has been demonstrated in penneabilized vascular smooth muscle and shown to depend on a G protein. Segments of rat tail artery were permeabilized with ATP and EGTA after prelabeling with [3H]inositol. Norepinephrine and GTPγS were both able to increase levels of IP, IP2, and IP3 in the segments. The effects of both norepinephrine and GTPγS on the segments was non-additive. Aluminum fluoride also increased inositol phosphates in intact segments and norepinephrine-stimulated increases in IP, IP2, and IP3 were insensitive to pertussis toxin.Keywords
This publication has 20 references indexed in Scilit:
- Direct regulation of smooth muscle contractile elements by second messengersBiochemical and Biophysical Research Communications, 1989
- Does the hydrolysis of inositol phospholipids lead to the opening of voltage operated Ca2+ channels in guinea-pig ileum? Studies with fluoride ions and caffeineBiochemical and Biophysical Research Communications, 1988
- In vitro synthesis of 32P-labelled phosphatidylinositol 4,5-bisphosphate and its hydrolysis by smooth muscle membrane-bound phospholipase CBiochemical and Biophysical Research Communications, 1987
- Angiotensin II stimulation of vascular smooth muscle phosphoinositide metabolism. State of the art lecture.Hypertension, 1987
- Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphateNature, 1987
- Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol esterBiochemical and Biophysical Research Communications, 1985
- Inositol-1,4,5-trisphosphate releases calcium from skinned cultured smooth muscle cellsBiochemical and Biophysical Research Communications, 1985
- Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesteraseNature, 1985
- Inositol 1,4,5-trisphosphate releases Ca2+ from intracellular store sites in skinned single cells of porcine coronary arteryBiochemical and Biophysical Research Communications, 1984
- Phospholipid degradation and signal translation for protein phosphorylationTrends in Biochemical Sciences, 1983