Relationship between X Chromosome Activation, Barr Body Frequency and Oestrogen Receptor Status in Human Breast Cancer: a Hypothesis

Abstract
Current evidence indicates an association between oestrogens, sex chromatin frequency and X chromosome activation in relation to the activity of the enzyme glucose-6-phosphate dehydrogenase. We suggest that a similar association might apply to control the level of oestradiol receptors in breast tumours and present information supporting this hypothesis.

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