A Practical Manufacturing Synthesis of 1-(R)-Hydroxymethyl-Dtpa: An Important Intermediate in the Synthesis of MRI Contrast Agents
- 1 July 1999
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 29 (14) , 2377-2391
- https://doi.org/10.1080/00397919908086243
Abstract
An efficient synthesis of alcohol 2 is described from L-Serine (OMe) in four synthetic steps. The process uses readily available reagents and is suitable for manufacturing.Keywords
This publication has 2 references indexed in Scilit:
- Synthesis of Enantiomerically Pure 1-(R)- and 1-(S)-Hydroxymethyl-Dtpa Penta-t-Butyl EstersViaChiral AminoalcoholsSynthetic Communications, 1996
- A Simple, High-Yielding Synthesis of N-t-Butoxycarbonyl α-Amino Esters: Precursors for α-Amino AldehydesSynthetic Communications, 1992