Nonoperative Management of Full-thickness Intravenous Extravasation Injuries in Premature Neonates Using Enzymatic Debridement

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Abstract
Peripheral intravenous fluid extravasation is a common occurrence among neonatal intensive care unit patients. Fifteen high-risk neonates, averaging less than 35 weeks' gestation and less than 1,500 g birth weight, with full-thickness extravasation injuries were successfully treated nonoperatively by a topical fibrinolysin/deoxyribonuclease ointment. All wounds healed without delaying hospital discharge, and no significant scar contractures -were observed in patients followed up to 16 months after injury.

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