Increases in CD3+CD4-CDS- T Lymphocytes in AIDS Patients with Disseminated Mycobacterium avium-intracellulare Complex Infection
Open Access
- 1 November 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 174 (5) , 969-976
- https://doi.org/10.1093/infdis/174.5.969
Abstract
Human immunodeficiency virus type 1 (HIV-1)-infected persons frequently have increased numbers of T cells bearing the γδ T cell receptor for antigen (γδ TCR). HIV-1–seropositive patients with < 100 CD4+ cells/rum3 were selected and divided into 9 AIDS-defining illness groups. The percentages of CD4+,CD8+, or double-negative CD4-CDS- (DN) T cells (most of the latter expressing the γδ TCR) for 8 symptomatic groups were compared with those for a reference group of asymptomatic HIV-1–infected patients. DN T cells were increased only in patients with disseminated Mycobacterium avium-intracellulare complex (MAC) infection, toxoplasmosis, or Kaposi's sarcoma. Multivariate logistic regression analysis revealed that the percentage of DN T cells was a better predictor of MAC infection than was the percentage of CD4+ T cells. The increased percentage of DN T cells might have important implications for the understanding of γδ T cell physiology and for the early diagnosis and management of MAC infections in AIDS patients.Keywords
This publication has 0 references indexed in Scilit: