Kallmann’s Syndrome — Beyond “Migration”
- 25 June 1992
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 326 (26) , 1775-1777
- https://doi.org/10.1056/nejm199206253262612
Abstract
THE analysis by Bick et al. in this issue of the Journal 1 closes the circle on a rapidly evolving set of discoveries that have implicated the function of a defined protein in neuronal migration. Specifically, these investigators have identified, as the common genetic mutation associated with Kallmann's syndrome in two brothers, a 3.3-kb deletion confined to the KALIG-1 locus on the short arm of the X chromosome. The deletion was also carried on one X chromosome of their unaffected mother.The defining clinical characteristics of Kallmann's syndrome are anosmia and hypogonadism. A series of stunning discoveries has revealed a rational . . .Keywords
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