CORYNEBACTERIUM-PARVUM AND CYCLOPHOSPHAMIDE AS COMBINATION TREATMENT FOR A MURINE MAMMARY ADENOCARCINOMA

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (4) , 1137-1140
Abstract
Weekly i.p. injections of killed C. parvum and cyclophosphamide (given on different days) inhibited growth of a transplantable murine mammary adenocarcinoma. A significant portion (40-80%) of animals could be made tumor free by combined therapy. No tumor free survivors were obtained with C. parvum alone, and tumor free mice were obtained with cyclophosphamide alone only at the expense of a high incidence of deaths due to drug toxicity. No evidence of tumor rejection immunity was detected in the tumor free survivors from the combined treatment protocols, suggesting that this therapeutic regimen is not associated with tumor rejection immunity.