Timing of cyclin D1 expression within G1 phase is controlled by Rho
- 5 October 2001
- journal article
- research article
- Published by Springer Nature in Nature Cell Biology
- Vol. 3 (11) , 950-957
- https://doi.org/10.1038/ncb1101-950
Abstract
The expression of cyclin D1 in mid-G1 phase is associated with sustained ERK activity, and we show here that Rho is required for the sustained ERK signal. However, we also report that Rho inhibits an alternative Rac/Cdc42-dependent pathway, which results in a strikingly early G1-phase expression of cyclin D1. Thus, cyclin D1 is induced in mid-G1 phase because a Rho switch couples its expression to sustained ERK activity rather than Rac and Cdc42. Our results show that Rho is crucial for maintaining the correct timing of cyclin D1 expression in G1 phase and describe a new role for cytoskeletal integrity in the regulation of cell cycle progression.Keywords
This publication has 40 references indexed in Scilit:
- A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survivalOncogene, 1999
- The extracellular matrix and mitogenic growth factors control G1 phase cyclins and cyclin-dependent kinase inhibitorsTrends in Cell Biology, 1997
- Human p21-activated kinase (Pak1) regulates actin organization in mammalian cellsCurrent Biology, 1997
- Involvement of the Small GTPase Rho in Integrin-mediated Activation of Mitogen-activated Protein KinasePublished by Elsevier ,1996
- Rhotekin, a New Putative Target for Rho Bearing Homology to a Serine/Threonine Kinase, PKN, and Rhophilin in the Rho-binding DomainJournal of Biological Chemistry, 1996
- Monoglucosylation of low-molecular-mass GTP-binding Rho proteins by clostridial cytotoxinsTrends in Cell Biology, 1995
- Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodiaCell, 1995
- G1 phase progression: Cycling on cueCell, 1994
- The small GTP-binding protein rac regulates growth factor-induced membrane rufflingCell, 1992
- The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsCell, 1992