RUTHENIUM-97 HEPATOBILIARY AGENTS FOR DELAYED STUDIES OF THE BILIARY-TRACT .1. RU-97 PIPIDA - CONCISE COMMUNICATION

  • 1 January 1981
    • journal article
    • research article
    • Vol. 22  (4) , 352-357
Abstract
Failure of early diagnosis of biliary atresia results in the development of cirrhosis and death. Commonly used hepatobiliary agents are not ideal for follow-up studies because of their unfavorable physical properties or short half-life. The excellent physical properties of Ru-97 should overcome these limitations. Therefore, Ru-97 PIPIDA (N,.alpha.-(p-isopropyl acetanilide) iminoacetic acid) is being investigated as a potential hepatobiliary agent that would allow an improved diagnosis of the disease. Ruthenium-97 PIPIDA and 99mTc PIPIDA showed similar blood clearance rates in dogs. Ru-97 PIPIDA scintigrams in dogs showed early uptake in liver and gallbladder and slow excretion through the gastrointestinal tract. Biodistribution studies were performed in normal rats and rats with biliary obstruction. Ru-97 PIPIDA should apparently be useful for delayed studies (1-3 days) of the biliary tract.