Acute Cholestatic Hepatitis with Rash and Hypereosinophilia Associated with Ranitidine Treatment
- 1 January 1993
- journal article
- case report
- Published by Taylor & Francis in Acta Clinica Belgica
- Vol. 48 (2) , 109-114
- https://doi.org/10.1080/17843286.1993.11718294
Abstract
We report a case of acute cholestatic hepatitis associated with rash and hypereosinophilia, in which the absence of transfusion, intercurrent viral infection, alcohol consumption or other hepatotoxic drugs are suggestive of ranitidine-induced hepatotoxicity. The pathogenesis of the disorder is unknown, but the lack of a dose-effect relationship, the rarity and unpredictability of the reaction, as well as the clinical signs suggest that hypersensitivity is involved. Physicians should be aware of this rare and idiosyncratic side-effect of ranitidine.Keywords
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