MECHANISM OF THYROID-CREATINURIA IN RELATION TO ADRENAL CORTEX

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Abstract
Thyroid-creatinuria induced by non-toxic doses of thyroid was found to be due to the manifestation of glucocorticoids action. It was difficult to induce this reaction in the absence of adrenal glands; however, administration of a small amount of cortisone made it reappear. The increased utilization of liver glycogen by thyroid hormone seemed to be the necessary condition of the induction of the glucocorticoids action. Both thyroid- and cortisone-creatinuria could be prevented by an increase in food intake. These creatinuria were accompanied by only a slight increase in the urinary output of guani-dinoacetic acid, the immediate precursor of creatine. This is contrary to the case in which exogenous creatine was administered for induction of creatinuria causing a marked increase in guanidino-acetic acid output with slight creatinuria.