Membrane protein insertion into the endoplasmic reticulum - another channel tunnel?
- 1 August 1992
- Vol. 14 (8) , 535-540
- https://doi.org/10.1002/bies.950140807
Abstract
The synthesis of biological membranes requires the insertion of proteins into a lipid bilayer. The rough endoplasmic reticulum of eukaryotic cells is a principal site of membrane biogenesis. The insertion of proteins into the membrane of the endoplasmic reticulum is mediated by a resident proteinaceous machinery. Over the last five years several different experimental approaches have provided information about the components of the machinery and how it may function.Keywords
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