Effect of Stable Strontium on Radiostrontium Excretion in Man

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Abstract
Parenterally administered stable strontium has been shown to be effective in decreasing the radio-strontium body burden in animals, whereas stable calcium is ineffective. In the present study, the effects of intravenously infused stable strontium and stable calcium, used in equimolar amounts as the gluconate, on urinary Sr85 excretion were investigated in man under constant and controlled dietary conditions. All patients received a low-calcium diet in the Metabolic Research Ward. A single tracer dose of Sr85Cl2 was given intravenously on the first day of the control and experimental studies. Infusions of stable strontium and stable calcium were given on 3 successive days in separate studies, the first infusion being given on the day of administration of Sr85. The Sr85 plasma levels and the urinary and fecal excretions were determined in the control, the stable strontium, and the stable calcium studies. Both stable strontium and stable calcium increased ithe urinary excretion of radiostrontium, infusions of stable strontium being somewhat more effective than infusions of stable calcium. Also, after the discontinuation of the stable strontium infusions, the urinary Sr85 excretions remained higher for several days than in the control and the stable calcium studies, stable strontium resulting in a significantly higher 10-day cumulative urinary Sr85 excretion than stable calcium. There was no effect of intravenous stable strontium or stable calcium on fecal Sr85 excretion.

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