Synthesis and Distribution of (─)-Mintsulfide, a Novel Sulfur-containing Sesquiterpene

Abstract
(─)-Mintsulfide [(─)-1], a new sulfur-containing sesquiterpene found in peppermint oil, was synthesized from (─)-germacrene-d[(─)-3] by a photochemical reaction and was confirmed to be (1R)-cis-2,6-epithio-cis-8-isopropyl-l-methyl-5-methylene-cis-bicyclo-[5,3,0]decane. The existence of 1 was confirmed in 13 of 74 essential oils analyzed.

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