The TF:VIIa Complex: Clinical Significance, Structure-function Relationships and Its Role in Signaling and Metastasis
- 1 January 2001
- journal article
- review article
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 86 (09) , 757-771
- https://doi.org/10.1055/s-0037-1616129
Abstract
In healthy humans, blood vessel-tissue factor is found primarily in the adventitia and thus physically separated from coagulation factors, which mainly circulate in an inactive form. Following injury, TF is exposed to blood and initiates the coagulation cascade. The resulting fibrin formation is an essential part for the initial repair of vessel damage to minimize blood-loss (reviewed by (1-4). Therefore, TF may be considered to form a hemostatic sheath around blood vessels essential for hemostasis and appears to be essential for life inasmuch as no TF deficiency has been reported and TF knockout mice do not survive beyond the perinatal period.Keywords
This publication has 98 references indexed in Scilit:
- Activation and Active Site Occupation Alter Conformation in the Region of the First Epidermal Growth Factor-like Domain of Human Factor VIIJournal of Biological Chemistry, 2000
- Exosite Interactions Determine the Affinity of Factor X for the Extrinsic Xase ComplexPublished by Elsevier ,2000
- Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant 1 1Edited by R. HuberJournal of Molecular Biology, 1999
- Kinetics of Human Factor VII ActivationBiochemistry, 1996
- Factor VIIa and the extracellular domains of human tissue factor form a compact complex: A study by X‐ray and neutron solution scatteringFEBS Letters, 1995
- Structure of the Ca2+-free GLA domain sheds light on membrane binding of blood coagulation proteinsNature Structural & Molecular Biology, 1995
- Procoagulant Human Monocytes Mediate Tissue Factor/Factor VIIa–Dependent Platelet-Thrombus Formation When Exposed to Flowing Nonanticoagulated Human BloodArteriosclerosis, Thrombosis, and Vascular Biology, 1995
- Identification of the Factor VIIa Binding Site on Tissue Factor by Homologous Loop Swap and Alanine Scanning MutagenesisBiochemistry, 1994
- Factor VIIa Residue Arg290 Is Required for Efficient Activation of the Macromolecular Substrate Factor XBiochemistry, 1994
- Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog.Circulation, 1983