Acute blood pressure effects of YC‐1‐induced activation of soluble guanylyl cyclase in normotensive and hypertensive rats

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Abstract
We used YC‐1 as a pharmacological tool to investigate the short‐term blood pressure effects of NO‐independent activation of sGC in normotensive and hypertensive rats. Four groups of normotensive Wistar‐Kyoto rats were treated by i.v. injection with vehicle (V), YC‐1 (YC‐1), sodium nitroprusside (SNP), or YC‐1 and SNP (YC‐1+SNP). Hypertension was induced in four additional groups of WKY rats by 3 weeks of oral treatment with L‐NAME. These animals were investigated with the same protocol as the normotensive animals: L‐NAME/V, L‐NAME/YC‐1, L‐NAME/SNP, L‐NAME/YC‐1+SNP. YC‐1 lowered mean arterial blood pressure (MAP) in normotensive and hypertensive animals similarly to SNP alone (PPBritish Journal of Pharmacology (2000) 130, 205–208; doi:10.1038/sj.bjp.0703320