EFFECT OF DIETHYLCARBAMAZINE IN A MURINE MODEL OF BRUGIA-MALAYI MICROFILARAEMIA

  • 1 January 1979
    • journal article
    • research article
    • Vol. 57  (2) , 329-330
Abstract
The effect of diethylcarbamazine [DEC] was tested in a murine model of B. malayi microfilaremia. A course of therapy similar to that used to treat human infection led to more than a 90% decrease in circulating parasites. Experiments in which different amounts of DEC were given as a single dose indicated that its microfilaricidal activity is dose-dependent. The animal model of B. malayi microfilaremia may be useful for studies of the mechanism of action and pharmacology of DEC and may be applied to the screening of new microfilaricidal drugs.