Impaired granulocyte adherence in mildly diabetic patients: effects of tolazamide treatment

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Abstract
Granulocyte adherence in 10 of 15 untreated asymptomatic hyperglycemic diabetic outpatients (mean fasting glucose ± SEM, 289 ± 16 mg/100 ml) was 62 ± 7% of control values. After treatment (2–4 wk) with tolazamide (500 mg daily), adherence to the nylon fiber columns employed in this study returned to control levels in the seven patients whose fasting glucose levels fell, (mean, 192 ± 16 mg/100 ml) and deteriorated in the three in whom fasting hyperglycemia worsened. Results of this study indicate that, even in some mildly diabetic patients, a reduction in granulocyte.adherence similar to that found in insulin-dependent diabetics may impair the inflammatory response.

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