Comparative deposition of inhaled aerosols in experimental animals and humans: A review
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 15 (2) , 197-214
- https://doi.org/10.1080/15287398509530647
Abstract
The biological effects of inhaled aerosols are often related to their site(s) of deposition within the respiratory tract. However, deposition patterns may differ between humans and those experimental animals commonly used in inhalation toxicology studies, making cross-species risk extrapolations difficult. This paper reviews the factors that control deposition and synthesizes much of the available data on comparative regional deposition.Keywords
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