EFFECT OF CASTRATION AND STEROIDS ON THE ARGINASE AND PHOSPHATASES OF THE ORGANS OF THE GUINEA PIG

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Abstract
Male guinea pigs were castrated at about 250 g. body wt. 35 days later they were implanted subcut. with pellets of the following steroids: 17-methyltestosterone; testosterone; testosterone propionate; 17-methylandrostanol-17 alpha, one-3; andro-stanol-17, one-3; 17-methylandrostanediol-3 alpha, 17 alpha; and androstanediol-3 alpha, 17 alpha. The dose of steroid was varied by the number of pellets implanted. Castration produced a decrease in the arginase activities of the kidney after 60 days, but not after 120 days. None of the steroids produced any remarkable changes. The greatest increase, 79%, was produced by 17-methyltestosterone, while testosterone was completely ineffective. The admn. of a relatively large dose, 12.5 mg./day, of testosterone propionate for 14 days produced only a 38% increase. Castration produced a decrease in the "alkaline" phos-phatase of the kidney, which was restored toward normal by the various steroids. None of the enzymes of the liver or the "acid" phosphatase of the kidney was affected by castration or the steroids.

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