DIABETOGENIC EFFECT OFSTILBESTROL IN FORCE-FED NORMAL AND PARTIALLY DEPANCREATIZED RATS

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Abstract
The adm. of stilbestrol to partially depancreatized non-glycosuric rats on a constant medium carbohydrate diet produced a severe glycosuria and hyperglycemia in all cases. Similar results were obtained with dihydrostilbestrol, estradiol and equilin. Massive doses of testosterone and methyl testosterone were weakly diabetogenic. The adm. of stilbestrol to normal non-glycosuric rats on a constant high carbohydrate diet produced a mild temporary glycosuria in the majority of cases.

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