Liver lipid metabolism and effect of cholesterol-lowering agents in the hyperlipidemia induced in rats by implantation of the pituitary-derived MtT-F4 tumor

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Abstract
Subcutaneous implantation of the transplantable pituitary tumor MtT-F4, which secretes large amounts of prolactin, growth hormone and ACTH, produces hyperlipidemia in < 30 days in the Fisher 344 rat. At the 35th day after implantation, the hypertriglyceridemia may begin to subside while the elevation of plasma cholesterol progresses. At this time, acetate incorporation by liver slices into cholesterol is increased 27-fold while incorporation into fatty acids is 9 times as high as in sham-operated rats. Probucol, hydroxymethylglutaric acid and clofibrate, drugs capable of lowering plasma cholesterol in these animals, also reduced the tumor-induced effect on cholesterol synthesis by .apprx. 60%. Only the latter 2 drugs, however, suppressed fatty acid synthesis to a similar extent. Enhanced hepatic synthesis of cholesterol apparently is partially responsible for the tumor-induced hypercholesterolemia.

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