Immunoglobulin Expression of Cells from Human Lymphoblastoid Lines

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Abstract
The interrelationship among surface, cellular, and secreted Ig in eight human lymphoblastoid lines was studied. Qualitative and quantitative data for cellular and secreted Ig paralleled each other. No “secretory block,” i.e., failure of an individual line to secrete cell-associated Ig, was observed. In contrast to the close relationship observed between cellular and secreted Ig, two lines showed a dissociation between the expression of surface, and that of cellular/secreted Ig. Previous data have raised the possibility of similarities between lymphoblastoid cells and immature B lymphocytes. The different patterns of Ig expression with respect to surface, cellular, and secreted Ig were consistent with a theoretical model for development of B lymphocytes. The significance of these observations was discussed.

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